Multiple approaches for CRISPR-based targeting of DNA methylation to promoters of bacterial and viral susceptibility genes in cassava
This study demonstrates that CRISPR/Cas9-based epigenome editing tools can successfully induce targeted DNA methylation at the promoters of susceptibility genes in cassava, thereby repressing their expression and conferring resistance to both bacterial blight and brown streak virus, although the resulting methylation patterns show limited stability across generations without the editing machinery.